Alcohol can interfere with some drugs, making them less effective. Alcohol can also intensify the side effects of some medications. This second interaction is what can happen when you mix ibuprofen and alcohol. In most cases, consuming a small amount of alcohol while taking ibuprofen is not harmful.
If you drink more, it takes longer to metabolize. The alcohol remaining in your body can still interact with ibuprofen. If you have consumed a small amount of alcohol, you should wait a day to take ibuprofen. If you drink heavily, wait at least two days to take ibuprofen.
It can take up to 24 hours to completely rid your system of ibuprofen, even though its effects generally last about 4 to 6 hours. According to the prescribing information, the ibuprofen half-life is about two hours. In case of an ibuprofen overdose, call 911 or Poison Control at 800-222-1222.